{"id":8614,"date":"2021-05-02T22:32:03","date_gmt":"2021-05-02T14:32:03","guid":{"rendered":"https:\/\/114kuaixue.com\/?p=8614"},"modified":"2022-09-15T23:26:52","modified_gmt":"2022-09-15T15:26:52","slug":"spike-protein-of-sars-cov-2-virus-alters-blood-brain-barrier-function","status":"publish","type":"post","link":"https:\/\/114kuaixue.com\/2021\/05\/02\/spike-protein-of-sars-cov-2-virus-alters-blood-brain-barrier-function\/","title":{"rendered":"SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8\uc774 \ud608\uc561-\ub1cc\uc7a5\ubcbd \uae30\ub2a5\uc744 \ubcc0\ud654\uc2dc\ud0a8\ub2e4"},"content":{"rendered":"<p>[2021\ub144 5\uc6d4 2\uc77c \ub370\uc77c\ub9ac\ud64d\ucf69] \ubbf8\uad6d \ud15c\ud50c \ub300\ud559 \uc5f0\uad6c\uc9c4\uc774 \ucf54\ub85c\ub09819 \ubc31\uc2e0\uc5d0 \ud3ec\ud568\ub418\uc5b4 \uc788\ub294 SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8 \ubd80\ubd84\uc758 \uc720\ud574\uc131\uc744 \ubc1d\ud600 \ubc31\uc2e0 \uc548\uc804\uc131 \ub17c\ub780\uc5d0 \uae30\ub984\uc744 \ubd80\uc5c8\ub2e4.<\/p><p class=\"has-small-font-size\">Tetyana P. Buzhdygan, Brandon J. DeOre, Abigail Baldwin-Leclair, Trent A. Bullock, Hannah M. McGary, Jana A. Khan, Roshanak Razmpour, Jonathan F. Hale, Peter A. Galie, Raghava Potula, Allison M. Andrews, Servio H. Ramirez, <a rel=\"noreferrer noopener\" class=\"keychainify-checked\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S096999612030406X\" target=\"_blank\">The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood\u2013brain barrier<\/a>, Neurobiology of Disease, Volume 146, 2020, 105131, ISSN 0969-9961, <a href=\"https:\/\/doi.org\/10.1016\/j.nbd.2020.105131\" rel=\"nofollow\">https:\/\/doi.org\/10.1016\/j.nbd.2020.105131<\/a><\/p><p>\uc2e0\uc885\ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4\uac10\uc5fc\uc99d(\ucf54\ub85c\ub09819)\uc744 \uc77c\uc73c\ud0a4\ub294 SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \uac10\uc5fc\ub418\uba74 \ub300\ub1cc \uc911\ucd94\uc2e0\uacbd\uacc4\uc758 \ud608\uad00\uc744 \ud3ec\ud568\ud55c \uc778\uccb4 \uc7a5\uae30 \uc2dc\uc2a4\ud15c\uc758 \ud608\uad00\uc5d0 \uc2ec\uac01\ud55c \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4\ub294 \uac83\uc740 \uc774\ubbf8 \ubc1d\ud600\uc9c4 \uc0ac\uc2e4\uc774\ub2e4.<\/p><p>SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uac00 \uc911\ucd94\uc2e0\uacbd\uacc4\uc5d0 \uac10\uc5fc\ub418\uba74 \uac10\uc5fc\ub418\uba74 \ub450\ud1b5, \ud5db\uad6c\uc5ed\uc9c8, \uc5b4\uc9c0\ub7ec\uc6c0 \ub4f1\uc758 \uc2e0\uacbd\ud559\uc801 \ubc18\uc751\uc5d0 \uc774\uc5b4 \uce58\uba85\uc801\uc778 \ubbf8\uc138 \ud608\uc804\uc774 \uc0dd\uae38 \uc218 \uc788\uc73c\uba70 \uac04\ud639 \ub4dc\ubb3c\uac8c\ub294 \ub1cc\uc5fc \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\uae30\ub3c4 \ud55c\ub2e4.<\/p><p>\uc5f0\uad6c\uc9c4\uc740 \uc774\ub7f0 \uc99d\uc0c1\uc744 \uc77c\uc73c\ud0a4\ub294 \uc6d0\uc778\uc774 SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8\uc774 \uc778\uccb4 \ub1cc\uc758 \ubaa8\uc138\ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\uc5d0 \uc790\ub9ac\uc7a1\uace0 \uc788\ub294 ACE2 \uc218\uc6a9\uccb4\uc5d0 \uc791\uc6a9\ud558\uae30 \ub54c\ubb38\uc784\uc744 \ubc1d\ud600\ub0c8\ub2e4.<\/p><p>\uc774\ub4e4\uc740 SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8 \ubd80\ubd84 \ub9cc\uc744 \ub5bc\uc5b4\ub2e4 \uc778\uccb4 \ub1cc\uc758 \ubaa8\uc138\ud608\uad00 \ub0b4\ud53c \uc138\ud3ec\uc5d0 \ubc18\uc751\uc2dc\ud0a4\ub294 \uc2e4\ud5d8\uc73c\ub85c \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8\uc774 \ud608\uc561-\ub1cc\uc7a5\ubcbd\uc744 \uae30\ub2a5\uc744 \ub5a8\uc5b4\ud2b8\ub824 \uc77c\uc885\uc758 \ub204\uc218 \ud604\uc0c1\uc774 \uc0dd\uae34\ub2e4\ub294 \uac83\uc744 \ud655\uc778\ud558\uc600\ub2e4. \ub610\ud55c \uc5f0\uad6c\uc9c4\uc740 \uace0\ud608\uc555 \ud658\uc790\ub4e4\uacfc \uce58\ub9e4 \ud658\uc790\ub4e4\uc5d0\uac8c ACE2 \uc218\uc6a9\uccb4\uac00 \ub354 \ub9ce\uc774 \ubc1c\ud604\ub418\uae30 \ub54c\ubb38\uc5d0 \uc704\ud5d8\ub3c4\uac00 \ub354 \ub192\ub2e4\uace0 \ud2b9\uc774 \uc0ac\ud56d\uc744 \ubd99\uc600\ub2e4.<\/p><p>\ud604\uc874\ud558\ub294 \ubaa8\ub4e0 \ucf54\ub85c\ub09819 \ubc31\uc2e0\uc740 SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc804\uccb4 RNA \uc124\uacc4\ub3c4 \uac00\uc6b4\ub370 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8 \uc81c\uc791 \ubd80\ubd84\uc744 mRNA, \uce68\ud32c\uc9c0 \uc544\ub370\ub178 \ub4f1 \ub2e4\uc591\ud55c \uc720\uc804\uc790 \ud3b8\uc9d1 \uae30\uc220\ub85c \uc778\uccb4\uc5d0 \uc804\ub2ec\ud558\ub294 \ubc29\uc2dd\uc774\ub2e4.<\/p><p>\ud558\uc9c0\ub9cc \uc774\ubc88 \uc5f0\uad6c \uacb0\uacfc\ub85c \ucf54\ub85c\ub09819 \ubc31\uc2e0\uc5d0 \ud3ec\ud568\ub418\uc5b4 \uc788\ub294 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8 \uc790\uccb4\uc5d0 \ub3c5\uc131\uc774 \uc788\ub2e4\ub294 \uac83\uc774 \ubc1d\ud600\uc9c0\uac8c \ub428\uc5d0 \ub530\ub77c SARS-CoV-2 \ud56d \ubc14\uc774\ub7ec\uc2a4 \uc57d\ubb3c \ub4f1 \ub300\uc548\uc774 \uc8fc\ubaa9\ubc1b\uace0 \uc788\ub2e4.<\/p><p class=\"has-text-align-center\">\ucc38\uace0: <a href=\"https:\/\/114kuaixue.com\/2021\/04\/27\/antiviral-drug-alternatives-attracting-attention-due-to-controversy-over-covid-19-vaccine-side-effects\/\">\ucf54\ub85c\ub09819 \ubc31\uc2e0 \ubd80\uc791\uc6a9 \ub17c\ub780 \ub54c\ubb38\uc5d0 \uc8fc\ubaa9 \ubc1b\ub294 \ud56d \ubc14\uc774\ub7ec\uc2a4 \uc57d\ubb3c\uacfc \ub300\uc548<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>[2021\ub144 5\uc6d4 2\uc77c \ub370\uc77c\ub9ac\ud64d\ucf69] \ubbf8\uad6d \ud15c\ud50c \ub300\ud559 \uc5f0\uad6c\uc9c4\uc774 \ucf54\ub85c\ub09819 \ubc31\uc2e0\uc5d0 \ud3ec\ud568\ub418\uc5b4 \uc788\ub294 SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8 \ubd80\ubd84\uc758 \uc720\ud574\uc131\uc744 \ubc1d\ud600 \ubc31\uc2e0 \uc548\uc804\uc131 \ub17c\ub780\uc5d0 \uae30\ub984\uc744 \ubd80\uc5c8\ub2e4. Tetyana P. Buzhdygan, Brandon J. DeOre, [&hellip;]<\/p>\n","protected":false},"author":192035308,"featured_media":8616,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"newspack_featured_image_position":"","newspack_post_subtitle":"","newspack_article_summary_title":"Overview:","newspack_article_summary":"","newspack_hide_updated_date":false,"footnotes":"","jetpack_publicize_message":"SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8\uc774 \ud608\uc561-\ub1cc\uc7a5\ubcbd\uc744 \uae30\ub2a5\uc744 \ubcc0\ud654\uc2dc\ud0a8\ub2e4 #Hongkong","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[561120],"tags":[2523377,2523318,2523102],"class_list":["post-8614","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-561120","tag-2523377","tag-2523318","tag-2523102","entry"],"jetpack_publicize_connections":[],"yoast_head":"\n<title>SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8\uc774 \ud608\uc561-\ub1cc\uc7a5\ubcbd \uae30\ub2a5\uc744 \ubcc0\ud654\uc2dc\ud0a8\ub2e4 - \ub370\uc77c\ub9ac\ud64d\ucf69<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/114kuaixue.com\/2021\/05\/02\/spike-protein-of-sars-cov-2-virus-alters-blood-brain-barrier-function\/\" \/>\n<meta property=\"og:locale\" content=\"ko_KR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8\uc774 \ud608\uc561-\ub1cc\uc7a5\ubcbd \uae30\ub2a5\uc744 \ubcc0\ud654\uc2dc\ud0a8\ub2e4 - \ub370\uc77c\ub9ac\ud64d\ucf69\" \/>\n<meta property=\"og:description\" content=\"[2021\ub144 5\uc6d4 2\uc77c \ub370\uc77c\ub9ac\ud64d\ucf69] \ubbf8\uad6d \ud15c\ud50c \ub300\ud559 \uc5f0\uad6c\uc9c4\uc774 \ucf54\ub85c\ub09819 \ubc31\uc2e0\uc5d0 \ud3ec\ud568\ub418\uc5b4 \uc788\ub294 SARS-CoV-2 \ubc14\uc774\ub7ec\uc2a4\uc758 \uc2a4\ud30c\uc774\ud06c \ub2e8\ubc31\uc9c8 \ubd80\ubd84\uc758 \uc720\ud574\uc131\uc744 \ubc1d\ud600 \ubc31\uc2e0 \uc548\uc804\uc131 \ub17c\ub780\uc5d0 \uae30\ub984\uc744 \ubd80\uc5c8\ub2e4. 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